RNA-Rocket Align your Illumina fastQ reads against supported genomes, view supported genomes, and estimate gene expression values using an RNA-Seq Pipeline running on Galaxy.
Host Response Data View Host Response proteomics and transcriptomics data collected and curated from multiple sources.
Pathogen Interaction Gateway Generate a network graph of Protein-Protein Interactions, including Host-Pathogen Interactions, from your custom selection of hosts/vectors, bacteria, viruses, and eukaryotic pathogens.
News & Announcements from the BRCs
Comparative analysis of response to selection with three insecticides in the dengue mosquito Aedes aegypti using mRNA sequencing.
21 Mar 2014-VectorBase
Aedes aegypti mosquitoes response to selection with 3 common insecticides was monitored using mRNA sequencing in a recent paper by David et. al. (2014).
8 Mar 2014-PATRICEnabling comparative modeling of closely related genomes: example genus Brucella
5 Feb 2014-IRDNext IRD Release
5 Feb 2014-ViPRJanuary 2014 ViPR Release
12 Dec 2013-Pathogen PortalHost Response Data Updated
6 May 2013-EuPathDBWorking with Parasite Database Resources - October 20-25, 2013
About the Pathogen PortalPathogen Portal's Infectious Disease Triangle perspective supports an integrative understanding of human disease through the study of multiple levels of interactions between a susceptible Host, an infectious Pathogen, and a conducive (to disease) Environment. Originating from plant pathology, this ecological approach is increasingly relevant to health sciences. Because some diseases include invertebrate Vectors as part of their ecology, the Disease Triangle broadly considers Environment to include Vectors.
The Pathogen Portal supports and links to five Bioinformatics Resource Centers (BRCs). Each BRC specializes in a different group of pathogens, focusing on, but not limited to, pathogens causing (Re-)Emerging Infectious Diseases, and those in the NIAID Category A-C Priority Pathogen lists for biodefense research. The scope of the BRCs also includes Invertebrate Vectors of Human Disease.
In addition to supporting, and serving as an entryway to, the BRCs, the Pathogen Portal's scientific focus is integrating host-response data that span the pathogens and vectors supported by the BRCs, thereby moving towards an integrative view of Host-Pathogen-Environment interactions, also known as the Disease Triangle. Originating from plant pathology, the concept of the Disease Triangle provides an ecological view of disease which is increasingly relevant to the Health Sciences. According to this view, disease arises when three criteria are met: an infectious Pathogen; a susceptible Host, and a conducive (to disease) Environment. Because some diseases include invertebrate Vectors as part of their ecology, the Disease Triangle broadly considers Vectors to be a component of the Environment.
The Pathogen Portal is developed and maintained by the CyberInfrastructure Division at the Virginia Bioinformatics Institute at Virginia Tech. New data and analysis tools are added regularly.
New data and analysis tools are added regularly to Pathogen Portal.